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标题：Combined Effects of Dietary Conjugated Linoleic Acid and Sesamin on Triacylglycerol and Ketone Body Production in Rat Liver
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作者：Masanobu SAKONO ; Kumiko YUJI ; Fumiko MIYANAGA 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2002
卷号：48
期号：5
页码：405-409
DOI：10.3177/jnsv.48.405
出版社：Center for Academic Publications Japan
摘要：The effects of a combination of dietary conjugated Linoleic acid (CLA) supplemented with Sesamin on hepatic ketogenesis and triacylglycerol secretion were compared using the livers of rats fed diets containing 1% CLA or linoleic acid (LA) in combination with 0.2% sesamin for 14 d, respectively. The feeding of CLA, as compared to LA, caused a significant reduction in the weight of perirenal adipose tissue but not that of epididymal adipose tissue, and affected neither growth parameters nor hepatic lipid concentration. Hepatic production of ketone bodies was consistently higher in rats fed CLA than in those fed LA, while triacylglycerol secretion was reversed. No significant difference was noted in the hepatic secretion of cholesterol among the groups. Although there was no effect of the dietary combination of CLA with sesamin on adipose tissue weight, hepatic lipid parameters and ketone body production were observed: i.e., triacylglycerol secretion tended to be reduced. These results suggest that the dietary combination of CLA with sesamin may be an effective approach for lowering serum triacylglycerol levels. The decreased hepatic secretion of triacylglycerol is, in part, due to enhanced fatty acid oxidation in the liver.
关键词：conjugated linoleic acid;sesamin;triacylglycerol;ketone body