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标题：Ethyl α-D-Glucoside Increases Urine Volume and Causes Renal Morphologic Changes in Rats
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作者：Tomoyuki MISHIMA ; Yumiko KATAYAMA ; Yoshie TAKAGI 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2005
卷号：51
期号：1
页码：22-26
DOI：10.3177/jnsv.51.22
出版社：Center for Academic Publications Japan
摘要：Ethyl α-D-glucoside (α-EG) is a peculiar component in sake, a traditional Japa-nese alcoholic beverage. In this study, morphological changes in kidney and effects on urine excretion by α-EG ingestion were investigated. After the rats were fed with pellet diets con-taining 10% or 20% α-EG dietary level, α-EG was detected in urine and urine volume showed significant increase (p<0.05). Kidney weights were increased (p<0.05) and renal tubules were dilated in the rats by α-EG ingestion, whereas there was no detectable histo-pathological damage to renal cells. Plasma uric acid and urea levels were not affected. In conclusion, ingested α-EG was excreted in urine, increasing urine volume. Increase in kid-ney weight related to renal tubule dilation was observed with α-EG ingestion without dete-riorate changes in the renal cells or functions.
关键词：Ethyl α-D-glucoside;kidney;histopathological test;urine volume;rat