文章基本信息

标题：ISOLATION OF BILOBALIDE AND GINKGOLIDE A FROM GINKGO BILOBA L. SHORTEN THE SLEEPING TIME INDUCED IN MICE BY ANESTHETICS
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作者：Keiji WADA ; Keiko SASAKI ; Ken-ichi MIURA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1993
卷号：16
期号：2
页码：210-212
DOI：10.1248/bpb.16.210
出版社：The Pharmaceutical Society of Japan
摘要：The leaves of (Ginkgo)___- (biloba)___- L. and aqueous extract from them shortened the sleeping time induced in mice by anesthetics (hexobarbital, α-chloralose and urethane, i.p.). Two characteristic terpenoids in (G.)___- (biloba)___-, bilobalide and ginkgolide A, significantly shortened the sleeping time induced by anesthetics.A toxic substance, 4-O-methylpyridoxine (MPN), responsible for "gin-nan food poisoning" isolated from the seed of (G.)___- (biloba)___-, was not detected from the extract of the leaves of (G.)___- (biloba)___-. Therefore, the Ginkgo biloba extract has no toxicities for MPN.
关键词：Ginkgo biloba;sleeping time;bilobalide;ginkgolide;anesthetic;4-O-methylpyridoxine