文章基本信息

标题：Effects of Dimethylpyrazine Isomers on Reproductive and Accessory Reproductive Organs in Male Rats
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作者：Kenji YAMADA ; Akinori SHIMIZU ; Akihiro OHTA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1993
卷号：16
期号：2
页码：203-206
DOI：10.1248/bpb.16.203
出版社：The Pharmaceutical Society of Japan
摘要：The effects of dimethylpyrazine isomers on reproductive and accessory reproductive organs in male rats were studied. Following the administration of 2, 5-dimethylpyrazine (100 mg/kg, s.c.), the weight of prostate and seminal vesicles, as well as testosterone levels in plasma were significantly decreased. One isomer of dimethylpyrazine, 2, 6-dimethylpyrazine (100 mg/kg, s.c.), affected only the seminal vesicles, while 2, 3-dimethylpyrazine had no influence on accessory reproductive organs. Following administration of 100 mg/kg of 2, 5-dimethylpyrazine, acid phosphatase activity in the prostate and fructose content in the seminal vesicles were also significantly decreased compared with tissues from vehicle-treated animals. Weight of the testes and acid phosphatase activity therein were not affected following the administration of 2, 5-dimethylpyrazine, nor were numbers of spermatozoa in the epididymis. These results showed that 2, 5-dimethylpyrazine induced decrease in prostate and seminal vesicle weight by inhibiting testosterone uptake and reducing plasma testosterone levels.
关键词：2, 5-dimethylpyrazine;reproductive organ;accessory reproductive organ;male rat