文章基本信息

标题：Distinct Effects of Clinically Used Anthracycline Antibiotics on ras Oncogene-Expressed Cells
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作者：Kayoko S. TSUCHIYA ; Toshie KANBE ; Makoto HORI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1993
卷号：16
期号：9
页码：908-911
DOI：10.1248/bpb.16.908
出版社：The Pharmaceutical Society of Japan
摘要：Doxorubicin, pirarubicin, and FAD-104, but not aclarubicin or MX 2, flattened the morphology of NIH3T3 cells that had been transformed by human H-ras and K-ras. The effect appeared on almost all cells, as early as 2 d following exposure to the antibiotics at concentrations inhibiting cell growth by 50% or more. The morphological alteration accompanied other nornal cell phenotypes, such as the restoration of actin atress fibers, anchorage dependence of cell growth and an increase in nucleoside diphosphate (NDP) kinase activity. NIH3T3 cells transformed by src and other tumor cell lines responded less prominently, if at all.
关键词：ras;anthracycline;morphology;actin fiber;anchorage independent growth;NDP kinase