文章基本信息

标题：Studies of Anti-cataract Drugs from Natural Sources. I. Effects of a Methanolic Extract and the Alkaloidal Components from Corydalis Tuber on in Vitro Aldose Reductase Activity
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作者：Michinori KUBO ; Hideaki MATSUDA ; Kiyoshi TOKUOKA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：3
页码：458-459
DOI：10.1248/bpb.17.458
出版社：The Pharmaceutical Society of Japan
摘要：The inhibitory effect of Corydalis tuber (Corydalis turtschaninovii BESSER forma yanhusuo Y. H. CHOU et C. C. HSU) was tested on crude rat lens aldose reductase, an enzyme involved in the complications of diabetes. The methanolic extract (CM-ext) inhibited aldose reductase, while the aqueous extract (CA-ext) was ineffective. Only dehydrocorydaline, of the seven alkaloidal components isolated from CM-ext, inhibited aldose reductase. It is suggested that the inhibitory effect of CM-ext on aldose reductase may be partially attributed to dehydrocorydaline.
关键词：Corydalis turtschaninovii forma yanhusuo;aldose reductase;alkaloid;dehydrocorydaline