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标题：Silymarin and Its Components Are Inhibitors of β-Glucuronidase
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作者：DongHyun KIM ; YoungHo JIN ; JongBeak PARK 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：3
页码：443-445
DOI：10.1248/bpb.17.443
出版社：The Pharmaceutical Society of Japan
摘要：Silymarin, a commercial crude drug used as a hepatoprotective, was found to inhibit 53% of β-glucuronidase activity at a final concentration of 0.8 mg/ml. Of three compounds A, silybin and C, which were isolated from silymarin, A and silybin potently inhibited the enzyme activity, followed by C. β-Glucuronidases of intestinal bacteria, HGU-1 and HGU-2, and E. coli HB101 were noncompetitively inhibited by silybin. β-Glucuronidase of the feces of a healthy human and of a human with colon cancer were also inhibited by silybin, silymarin and saccharic acid 1, 4-lactone at 0.03-0.15 mg/ml. Silymarin and silybin protected the increase in enzyme activity in the serum of the rats treated with CCl₄.
关键词：β-glucuronidase;silymarin;silybin;colon cancer;liver;intestinal bacteria