文章基本信息

标题：Digestion of Endothelin-1 on Cultured Vascular Smooth Muscle Cells
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作者：Toshiyuki EDANO ; Koichi ARAI ; Tomoyuki KOSHI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：3
页码：376-378
DOI：10.1248/bpb.17.376
出版社：The Pharmaceutical Society of Japan
摘要：The degradation of ¹²⁵I-endothelin-1 (¹²⁵I-ET-1) was examined on cultured porcine aortic endothelial cell (EC) and rat vascular smooth muscle cell (SMC) by HPLC analysis. The degradation of ET-1 was observed on SMC and was slightly observed on EC. Membrane fractions of SMC had a strong potency for the degradation of ET-1 and retained activity even in plasma. This activity was inhibited with some of the noble inhibitors which were known as enkephalinase inhibitors. These results suggest that endothelin degradation enzyme on SMC is related to enkephalinase and that this enzyme plays a significant role in the degradation of ET-1 in vivo.
关键词：endothelin-1 degradation;endothelin-1 digestion;vascular smooth muscle cell;cultured vascular smooth muscle cell;enkephalinase;neutral endopeptidase