文章基本信息

标题：Accelerative Effect of Shikonin, Alkannin and Acetylshikonin on the Proliferation of Granulation Tissue in Rats
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作者：Yukihiro OZAKI ; Akiko OHNO ; Yuji SAITO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：8
页码：1075-1077
DOI：10.1248/bpb.17.1075
出版社：The Pharmaceutical Society of Japan
摘要：The present study was carried out to compare the accelerative effect of shikonin (R-type), alkannin (S-type), and acetylshikonin on the proliferation of granulation tissue in rats, and to elucidate the correlation between the potency of the effect and their optical activity. Koushikon mainly contained the R-type of acetylshikonin, and Nanshikon mainly contained the S-type of acetylshikonin. Each compound produced a dose-dependent acceleration of the cotton pellet-induced granuloma formation. In comparing identical doses of shikonin, alkannin and acetylshikonin, the potency of their accelerative effects on the proliferation of granulation tissue was about the same. This result suggests that their absolute configurations (R-type or S-type) and their acetylation on the hydroxy group of the sidechain of shikonin or alkannin may not be important in producing the effect.
关键词：shikonin;alkannin;acetylshikonin;optically active isomer;granulation tissue proliferation