文章基本信息

标题：The Core Structure of Ginsenan PA, a Phagocytosis-Activating Polysaccharide from the Root of Panax ginseng
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作者：Masashi TOMODA ; Keiko HIRABAYASHI ; Noriko SHIMIZU 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：9
页码：1287-1291
DOI：10.1248/bpb.17.1287
出版社：The Pharmaceutical Society of Japan
摘要：Controlled Smith degradation and limited hydrolysis of ginsenan PA, the main phagocytosis-activating polysaccharide isolated from the root of Panax ginseng C. A. MEYER, were performed. The reticuloendothelial system-potentiating and anti-complementary activities of the degradation products were investigated. Methylation analysis of the primary and secondary Smith degradation products indicated that the core structural features of ginsenan PA include a backbone chain mainly composed of β-1, 3-linked D-galactose. Almost half of the galactose units in the backbone carry side-chains composed of β-1, 6-linked D-galactosyl residues at position 6. Further 3, 6-branching of D-galactose units was observed in a part of the side-chains. α-L-Arabinose units are connected mainly to the core galactose moieties via position 6. Removal of most of the arabinose units had a considerable effect on immunological activity.
关键词：ginseng;polysaccharide;core structure;Smith degradation;de-arabinosylation;immunological activity