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  • 标题:Effect of Polygonati Rhizoma on Blood Glucose and Facilitative Glucose Transporter Isoform 2 (GLUT2) mRNA Expression in Wistar Fatty Rats
  • 本地全文:下载
  • 作者:Toshihiro MIURA ; Atsushi KATO ; Masaru USAMI
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:1995
  • 卷号:18
  • 期号:4
  • 页码:624-625
  • DOI:10.1248/bpb.18.624
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:The intraperitoneal administration of the methanol extract of Polygonati Rhizoma (OM) to Wistar fatty rats caused a significant decrease in the blood glucose level 4 h after its administration at 800 mg/kg (p<0.01). The hepatic content of facilitative glucose transporter isoform 2, liver type glucose transporter (GLUT2) mRNA content from rat liver significantly decreased in the intraperitoneally OM-treated rats compared to that in the controls (p<0.01). These results suggest that the hypoglycemic effect of OM is presumably due, at least in part, to the reduction of GLUT2 mRNA expression. Because of this unique therapeutic mechanism, OM could be a new category of therapeutic agent for non-insulin-dependent diabetes mellitus.
  • 关键词:hypolycemic activity;Polygonati Rhizoma;Wistar fatty rat;facilitative glucose transporter isoform 2 (GLUT2);northern blotting
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