文章基本信息

标题：In Vitro Antitumor Activity of Polymyxin Acylase from Pseudomonas sp. M-6-3
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作者：Noriko YASUDA ; Hisami MATSUNAGA ; Yukio KIMURA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1995
卷号：18
期号：4
页码：615-617
DOI：10.1248/bpb.18.615
出版社：The Pharmaceutical Society of Japan
摘要：Polymyxin acylase from Pseudomonas sp. M-6-3 can deacylate not only polymyxin group antibiotics, but also the long-chain fatty acyl group of proteins and peptides. We found the in vitro antitumor activity of polymyxin acylase against murine and human tumor cells, especially KB cells. The mechanism of the antitumor activity remains equivocal, but we speculate that it may result from the affinity of polymyxin acylase for long-chain fatty acyl proteins in human carcinoma cells.
关键词：polymyxin acylase;antitumor activity;KB cell