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标题：Effect of Saiko-ka-ryukotsu-borei-to on the Stress-Induced Increase of Serum Corticosterone in Mice
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作者：Kenroh SASAKI ; Kenichi SUZUKI ; Fumihiko YOSHIZAKI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1995
卷号：18
期号：4
页码：563-565
DOI：10.1248/bpb.18.563
出版社：The Pharmaceutical Society of Japan
摘要：The effect of Saiko-ka-ryukotsu-borei-to (SRBT) on the stress-induced enhancement of serum corticosterone in various stress models was investigated in mice. The serum corticosterone was elevated significantly by immobilized stress, forced-swim stress, electric-shock stress, psychological stress and conditioned-fear stress, respectively. The concentration in the last two models was decreased in a dose-dependent manner by pre-administration of SRBT (10, 60, 100, 600 and 1000 mg/kg, p.o.). Therefore, this action seems to be effective in stress involving emotional factors but ineffective in physical stress models. These results indicate that the anti-stress effect of SRBT is dependent strongly on the degree of psychological change compared with physical change in mice.
关键词：Saiko-ka-ryukotsu-borei-to;diazepam;serum corticosterone;anti-stress effect;stress model;mouse