文章基本信息

标题：HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECT OF CHITOSAN IN NORMAL AND NEONATAL STREPTOZOTOCIN-INDUCED DIABETIC MICE
本地全文：下载
作者：Toshihiro MIURA ; Masaru USAMI ; Yoshiyuki TSUURA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1995
卷号：18
期号：11
页码：1623-1625
DOI：10.1248/bpb.18.1623
出版社：The Pharmaceutical Society of Japan
摘要：The hypoglycemic and hypolipidemic effect of chitosan was investigated in normal and neonatal streptozotocin-induced diabetic (NSZ) mice, one of the animal models of lean type non-insulin-dependent diabetes mellitus (NIDDM) with hypoinsulinaemia. Chitosan (5% food admixture) reduced the blood glucose (P<0.01), cholesterol (P<0.01) and triglyceride (P<0.01) of normal mice after 4 weeks, and also significantly lowered the blood glucose (P<0.05) and cholesterol (P<0.05) of NSZ mice under the same conditions. But these parameters of KK-Ay mice, which exhibit obese type NIDDM with hyperinsulinaemia, were not affected by chitosan administration. It is concluded that chitosan would be useful for the treatment of lean type NIDDM with hypoinsulinaemia.
关键词：chitosan;hypoglycemic effect;hypolipidemic effect;normal mice;neonatal streptozotocin-induced diabetic mice;KK-Ay mice