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标题：Selective Induction of Cell Death in Cancer Cells by Gallic Acid
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作者：Makoto INOUE ; Rie SUZUKI ; Nahoko SAKAGUCHI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1995
卷号：18
期号：11
页码：1526-1530
DOI：10.1248/bpb.18.1526
出版社：The Pharmaceutical Society of Japan
摘要：Gallic acid (3, 4, 5-trihydroxybenzoic acid) is a naturally occurring plant phenol obtained by the hydrolysis of tannins and is known to show some pharmacological activities. In screening anti-cancer agents in traditional Chinese medicines, gallic acid was found to show cytotoxicity against all cancer cells that we examined in this study (IC₅₀s : 4.8-13.2 μg/ml). Gallic acid, however, showed no cytotoxicity against primary cultured rat hepatocytes and macrophages, and lesser cytotoxicity against fibroblasts and endothelial cells. Cell death in dRLh-84 cells occurred within 6h after gallic acid treatment at a concentration of more than 20μg/ml. A study of structurally related compounds suggested that the cytotoxicity shown by gallic acid was not a common feature in phenolic compounds, but was a fairly specific characteristic of gallic acid. That is, three adjacent phenolic hydroxyl groups of gallic acid were responsible for the cytotoxicity, and the carboxyl group was not responsible, but seemed to be implicated in distinguishing between normal cells and cancer cells.
关键词：gallic acid;plant phenol;selective cytotoxicity;antioxidant