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标题：The Effects of Peripheral Serotonin2 (5-HT2) and Serotonin3 (5-HT3) Receptor Agonists on Blood Glucose Levels in Rats
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作者：Yumi SUGIMOTO ; Jun YAMADA ; Tomoko YOSHIKAWA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1996
卷号：19
期号：10
页码：1384-1386
DOI：10.1248/bpb.19.1384
出版社：The Pharmaceutical Society of Japan
摘要：The involvement of the peripheral serotonin_2A (5-HT_2A) receptor in α-methyl-5-HT-induced hyperglycemia was examined in rats. The 5-HT_2A receptor antagonist, ketanserin, significantly inhibited α-methyl-5-HT-elicited hyperglycemia. Taken together with a previous report that 5-HT-induced hyperglycemia was prevented by ketanserin, it is suggested that the periperal 5-HT_2A receptor participates in glucose regulation. As α-methyl-5-HT increased serum insulin but did not affect glucagon levels, it is indicated that these pancreatic hormones are probably not related to α-methyl-5-HT-induced hyperglycemia. Moreover, the peripheral 5-HT₃ receptor agonist, 2-methyl-5-HT, did not affect blood glucose, insulin or glucagon levels. Our results therefore suggest that the peripheral 5-HT₃ receptor is not involved in glucose regulation.
关键词：peripheral 5-HT2 receptor;peripheral 5-HT3 receptor;blood glucose;insulin;glucagon