文章基本信息

标题：Stimulation of Sarcoplasmic Reticulum Ca2+-ATPase by Gingerol Analogues
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作者：Yasushi OHIZUMI ; Susumu SASAKI ; Kazuki SHIBUSAWA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1996
卷号：19
期号：10
页码：1377-1379
DOI：10.1248/bpb.19.1377
出版社：The Pharmaceutical Society of Japan
摘要：We have reported previously that [8]-gingerol increased Ca²⁺-ATPase activity. ^{1, 2)}Here we synthesized gingerol related compounds (AP-004, AP-005 and AP-015) and investigated the effects of gingerols ([6]-gingerol, [8]-gingerol and [10]-gingerol) and the synthesized compounds on the Ca²⁺-ATPase activity of sarcoplasmic reticulum (SR). The Ca²⁺-ATPase activity and the Ca²⁺-pumping activity increased by these compounds in a concentration-dependent manner. It is probable that both the o-methoxyphenol and hydrocarbon chain in the molecule of gingerol analogues are necessary for the activation of the Ca²⁺-pumping ATPase activity of SR.
关键词：gingerol;Ca2+-pumping ATPase;sarcoplamic reticulum