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标题：Relationship between Pharmacokinetics and the Analgesic Effect of Indomethacin in the Rat
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作者：Toyofumi SUZUKI ; Taiyo SUGANUMA ; Ryo SHIMIZU 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1997
卷号：20
期号：4
页码：438-442
DOI：10.1248/bpb.20.438
出版社：The Pharmaceutical Society of Japan
摘要：The relationship between the pharmacokinetic properties and the analgesic effect of indomethacin (IDM) was evaluated on a carrageenin-induced inflammation model in the rat. Rats were administered the drug in one of two ways : intravenous (i.v.) IDM bolus or i.v. IDM infusion. The analgesic activity was measured by Randall-Selitto test. No correlation was observed between the analgesic effect and the plasma IDM concentration after i.v. bolus administration of IDM. However, in the case of infusion, IDM produced a dose-dependent analgesic effect. In this paper, we demonstrated that the plasma concentration of IDM maintained by i.v. infusion had a prolonged analgesic effect on the carrageenin-induced inflammation model.
关键词：indomethacin;pharmacokinetics;analgesic effect