文章基本信息

标题：Hepatoprotective Effect of Hovenia dulcis THUNB. on Experimental Liver Injuries Induced by Carbon Tetrachloride or D-Galactosamine : Lipopolysaccharide
本地全文：下载
作者：Koji HASE ; Mizue OHSUGI ; Quanbo XIONG 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1997
卷号：20
期号：4
页码：381-385
DOI：10.1248/bpb.20.381
出版社：The Pharmaceutical Society of Japan
摘要：The hepatoprotective effects of the fruits of Hovenia dulcis THUNB. on chemically or immunologically induced experimental liver injury models were examined. The methanol extract showed significant hepatoprotective activity against CCl₄-toxicity in rats and D-galactosamine (D-GaIN)/lipopolysaccharide-induced liver injury in mice. The methanol extract also significantly protected against CCl₄-toxicity in primary cultured rat hepatocytes. Hepatoprotective activity-guided fractionation and chemical analysis led to the isolation of an active constituent, (+)-ampelopsin (1) from the methanol extract.
关键词：Hovenia dulcis;(+)-ampelopsin;hepatoprotective effect;lipopolysaccharide;D-galactosamine;carbon tetrachloride