文章基本信息

标题：POTENT RETINOID SYNERGISTS WITH A DIPHENYLAMINE SKELETON
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作者：Kiminori OHTA ; Motonori TSUJI ; Emiko KAWACHI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1998
卷号：21
期号：5
页码：544-546
DOI：10.1248/bpb.21.544
出版社：The Pharmaceutical Society of Japan
摘要：4-[N-(5, 6, 7, 8-Tetrahydro-5, 5, 8, 8-tetramethyl-2-naphthyl)amino]benzoic acid (5) exhibited weak retinoidal and retinoid synergistic activities in HL-60 cell differentiation assay. N-Alkylation of 5 caused decrease or loss or differentiation-inducing activity, but enhanced the synergistic activity with a synthetic retinoid Am80 (2), as reflected in the potent synergistic EC₅₀ (SEC₅₀) values of DA023 (11, 1.6×10^-10 M) and DA113 (14, 1.4×10^-10 M) in the presence of 1.0×10^-10 M Am80 (2).
关键词：retinoid;retinoic acid;synergist;cell differentiation