文章基本信息

标题：Inhibitory Effect of 2, 5-Dimethylpyrazine on Oxytocic Agent -induced Uterine Hypercontraction of Normal or Pregnant Female Rats
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作者：Kenji Yamada ; Yoshiharu Kobayashi ; Hisato Fujihara 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1998
卷号：21
期号：5
页码：538-540
DOI：10.1248/bpb.21.538
出版社：The Pharmaceutical Society of Japan
摘要：Intraperitoneal administration of 2, 5-dimethylpyrazine (2, 5-DMP) was found to inhibit oxytocin- and prostaglandin F_2α -induced tetanic uterine contractions in normal or pregnant female rats. This suggests that 2, 5-DMP may be used as a countercontraction agent or relaxant for preventing oxytocic agent-induced medical accident including uterine rupture or pressure death of the fetus due to uterine contractions.
关键词：2, 5-Dimethylpyrazine;Rat uterus;Contraction;Oxytocin;Prostaglandin F2α