文章基本信息

标题：Synthesis of a Biologically Active Fluorescent Derivative of GM1, a Main Ginseng Saponin Metabolite Formed by Intestinal Bacteria
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作者：Hideo HASEGAWA ; Ryuichi SUZUKI ; Chisato WAKABAYASHI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1998
卷号：21
期号：5
页码：513-516
DOI：10.1248/bpb.21.513
出版社：The Pharmaceutical Society of Japan
摘要：A fluorescent derivative of GM1 [20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol], a main Ginseng saponin metabolite formed by intestinal bacteria, was obtained from the condensation of its trisnor-aldehyde derivative with dansyl hydrazine. The dansylated GM1 fluoresced strongly and showed almost the same properties as its parent compound in lipophilicity and biological activities, so this fluorescent compound might provide an insight into the mechanism of pharmacological activities of GM1.
关键词：ginsenoside;intestinal bacterial metabolite;dansylation;20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol (GM1);biologically active fluorescent probe