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标题：Anthraquinones from Neonauclea calycina and Their Inhibitory Activity against DNA Topoisomerase II
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作者：Hideki TOSA ; Munekazu IINUMA ; Fujio ASAI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1998
卷号：21
期号：6
页码：641-642
DOI：10.1248/bpb.21.641
出版社：The Pharmaceutical Society of Japan
摘要：In a series of searches fot DNA topoisomerase II inhibitors from naturally occurring compounds, a wood extract of Neonauclea calycina MERR. (Rubiaceae) showed a moderate effect in vitro. Purification of the extract resulted in the isolation of seven known anthraquinones. The structures were characterized as damnacanthal, rubiadin 1-methyl ether, nordamnacanthal, morindone, damnacanthol, lucidin 3-O-primeveroside and morindone 6-O-primeveroside by spectral analysis, respectively. Damnacanthal and morindone showed an intensive inhibitory effect against topoisomerase II (IC₅₀ : 20μg/ml and 21μg/ml).
关键词：Neonauclea calycina;Rubiaceae;anthraquinone;damnacanthal;morindone;topoisomerase II inhibitory activity