文章基本信息

标题：Effect of Sulfated Compounds on Acid Sialidase
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作者：Megumi NAGAOKA ; Takayuki SHIRAISHI ; Kimio FURUHATA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1998
卷号：21
期号：11
页码：1134-1138
DOI：10.1248/bpb.21.1134
出版社：The Pharmaceutical Society of Japan
摘要：The inhibitory effects of various sulfated compounds on the activitives of sialidases purified from porcine liver and human placenta were investigated. Among the sulfated compounds tested, heparin, dextran sulfate, condroitin sulfates and sulfatide significantly inhibited the 4-methylumbelliferyl-α-N-acetylneuraminic acid (4-MU-NeuAc) sialidase activities of the two enzyme preparations, but glucose 6-sulfate and glucosamine 6-surfate did not. Potassium sulfate showed an inhibitory effect only at high concentrations. When the sialidase activities were measured using natural substrates, the sialidase activities for the (α2-3) and (α2-6) sialyllactoses, and colominic acid, were markedly inhibited by heparin and sulfatide similar to 4-MU-NeuAc, although the fetuin sialidase activity was not significantly influenced by them. The sialidase activity hydrolyzing GM3 was strongly inhibited by heparin, but not by sulfatide.
关键词：sialidase;neuraminidase;sulfated compound;inhibitory effect