文章基本信息

标题：An NADPH-Dependent Reductase in Neonatal Pig Testes That Metabolizes Androgens and Xenobiotics
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作者：Shizuo NAKAJIN ; Noriko MINAMIKAWA ; Michael E. BAKER 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1998
卷号：21
期号：12
页码：1356-1360
DOI：10.1248/bpb.21.1356
出版社：The Pharmaceutical Society of Japan
摘要：We have isolated an NADPH-dependent reductase from neonatal pig testes that metabolizes andorogens and a variety of xenobiotics. This enzyme is distinct from 3α/β, 20β-hydroxysteroid dehydrogenase or its homologue, carbonyl reductase, as judged by its immunological and molecular properties and its much narrower specificity for steroids. This reductase and 3α/β, 20β-hydroxysteroid dehydrogenase may be part of a mechanism for regulating androgen levels the neonatal pig testes. Interestingly, we could not find multiple isoforms of 3α/β, 20β-hydroxysteroid dehydrogenase/carbonyl reductase in pig testes unlike human and rat testes and other organs in which multiple isoforms are expressed.
关键词：NADPH-dependent reductase;3α/β, 20β-hydroxysteroid dehydrogenase;carbonyl reductase;androgen;xenobiotic;purification