文章基本信息

标题：Stimulation of Cellular XTT Reduction by Cytochrome Oxidase Inhibitors
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作者：Setsuko KUNIMOTO ; Chisato NOSAKA ; Tomio TAKEUCHI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1999
卷号：22
期号：6
页码：660-661
DOI：10.1248/bpb.22.660
出版社：The Pharmaceutical Society of Japan
摘要：XTT reducing activity by CHO and L1210 cells was found to be stimulated by the presence of cytochrome oxidase inhibitors such as NaN₃ or KCN. Among the other respiratory chain inhibitors, antimycin A (a complex III inhibitor) and chlorpromazine inhibited cellular XTT reduction, and rotenone and malonate showed sligth inhibition and no effect, respectively. It is suggested that XTT reduction is coupled with the respiratory chain via cytochrome c, which is located between complexes III and IV (cytochrome oxidase).
关键词：XTT;cytochrome oxidase;NaN3;KCN