文章基本信息

标题：Anti-carcinogenic Activity of Taraxacum Plant. II
本地全文：下载
作者：Midori TAKASAKI ; Takao KONOSHIMA ; Karukuni TOKUDA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1999
卷号：22
期号：6
页码：606-610
DOI：10.1248/bpb.22.606
出版社：The Pharmaceutical Society of Japan
摘要：Eleven triterpenoids (1-11) form the roots of Taraxacum japonicum (Compositae) were examined for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) induced by the tumor promoter, 12-O-tetrade canoylphorbol-13-acetate (TPA), in Raji cells as a primary screening test for anti-tumor-promoters (cancer chemopreventive agents). Of these triterpenoids, traxasterol (1) and taraxerol (7) exhibited significant inhibitory effects on EBV-EA induction, but the inhibitory effects of their acetates 2 and 8 were weaker than those of and 7. Furthermore, 1 and 7 exhibited potent anti-tumor-promoting activity in the two-stage carcinogenesis tests of mouse using 7, 12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter, and 1 showed a remarkable inhibitory effect on mouse spontaneous mammary tumors using C3H/OuJ mouse. These results strongly suggested that traxasterol (1) could be a valuable chemopreventive agent.
关键词：taraxasterol;taraxerol;anti-carciogenic activity;Taraxacum japonicum;mouse skin tumor;mouse mammary tumor