文章基本信息

标题：Antioxidative Activity of Indenestrol A, a Diethylstilbestrol Metabolite
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作者：Taiko ODA ; Megumi EBATA ; Shigenobu MATSUMOTO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1999
卷号：22
期号：6
页码：586-589
DOI：10.1248/bpb.22.586
出版社：The Pharmaceutical Society of Japan
摘要：To elucidate the various activities of synthetic estrogens, the antioxidative activities of diethylstilbestrol(DES) and related metabolic analogs were examined. The antioxidative activities were assessed in terms of the inhibitory effect on Fe²⁺-and ascorbic acid-induced peroxidation of egg phosphatidylcholine (egg PC), and also superoxide scavenging ability using cyclic voltametry. Moreover, after in vivo administration of the test compounds to mice, the animals were subjected to hyperoxia, and catalase, glutathione peroxidase and superoxide dismutase activities in the brain, lungs and liver were measured. The results indicated that indenestrol A, one of the metabolites of DES, had the strongest antioxidative activity among the test compounds under both in vivo and in vitro conditions.
关键词：antioxidative activity;indenestrol A;thiobarbituric acid reactive substance;superoxide dismutase;glutathione peroxidase