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标题：Improvement in the Turnover Rate of the Stratum Corneum in False Aged Model Rats by the Administration of Geniposidic Acid in Eucommia ulmoides OLIVER Leaf
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作者：Yanmei LI ; Koichi METORI ; Katsuya KOIKE 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1999
卷号：22
期号：6
页码：582-585
DOI：10.1248/bpb.22.582
出版社：The Pharmaceutical Society of Japan
摘要：We earlier reported that collagen synthesis in false aged model rats was stimulated by the administraion of a methanol extract from the leaves of Eucommia ulmoides OLIVER. When the methanol extract was fractionated to n-hexane, ethyl acetate, acetone and methanol fractions by silica gel chromatography, we discovered that geniposidic acid and sucubin, contained in the acetone fraction, were the active ingredients. In the current study, we set out to examine if active compounds found in the Eucommia ulmoides OLIVER leaf (EUOL) improved the low turnover rate in the stratum corneum of false aged model rats. The turnover rate in the stratum corneum in rats we measured as 50% dansyl chloride clearance day. In the first experiment, administration of a 2.4% water soluble methanol extract (WSME) of EUOL, along with an 11% protein diet, led to a 20% higher turnover rate in the stratum corneum (p<0.05, Mann-Whitney) than the control value. The WSME mainly contained iridoid mono-glycosides such as geniposidic acid. In the second experiment, treatment with geniposidic acid similarly caused a higher turnover rate in the stratum corneum, increasing turnover by 23% (p<0.05, Mann-Whitney)compared to the control value. In this paper we reveal that the WSME contains compounds effective against aging, and one of them is geniposidic acid.
关键词：Eucommia ulmoide OLIVER;leaf;geniposidic acid;stratum corneum;dansyl chloride rat