文章基本信息

标题：Effect of 3, 6-Dimethylpyrazine-2-thiol on Androstenedione-Induced Increase of Uterine Weight in Female Rats
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作者：Kenji YAMADA ; Sohei SUGAWARA ; Keiko OHMORI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1999
卷号：22
期号：12
页码：1380-1381
DOI：10.1248/bpb.22.1380
出版社：The Pharmaceutical Society of Japan
摘要：3, 6-Dimethylpyrazine-2-thiol administered at 10-70 mg/kg, p.o. was found to suppress androstenedione-in-duced increase of uterine weight in female rats. This action was weaker than that of aminoglutethimide (3-30 mg/kg, p.o.). After administration of androstenedione, increased plasma estradiol levels were reduced by 3, 6-dimethylpyrazine-2-thiol. Moreover, in vitro, production of estradiol in the pregnant mare serum gonadotropin (PMSG)-treated ovary was inhibited by 3, 6-dimethylpyrazine-2-thiol. These results suggest that 3, 6-dimethylpyrazine-2-thiol has an inhibitory action on aromatase activity.
关键词：androstenedione;3, 6-dimethylpyrazine-2-thiol;aminoglutethimide;uterine weight