文章基本信息

标题：Experimental Allergic Conjunctivitis in Guinea Pigs Induced by Japanese Cedar Pollen
本地全文：下载
作者：Miho TAKADA ; Tamao YAMADA ; Hiroto NAKAHARA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2000
卷号：23
期号：5
页码：566-569
DOI：10.1248/bpb.23.566
出版社：The Pharmaceutical Society of Japan
摘要：We report a new experimental allergic conjunctivities with Japanese cedar pollen as antigen in guinea pigs, and the immunological characteristics of this model were also elucidated. Allergic conjunctivitis was developed by immunization in guinea pigs with a mixture containing Japanese cedar pollen and killed Bordetella pertussis. When local application of Japanese ceder pollen suspension 14 d after systemic immunization was performed every 3 d, remarkable conjunctivitis was observed from 20 to 35 d. Increase in vascular permeability and decrease in histamine contents of the conjunctiva were also observed after local application of antigen. Passive cutaneous anaphylactic (PCA) reactions revealed that both IgG- and IgE-rich antibodies were produced in this model. Chlorpheniramine, ketotifen and levocabastine were effective in inhibiting cedar pollen-induced conjunctivities. Although a high concentration was needed, tranilast and amlexanox also showed significant inhibition of conjunctivitis induced by cedar pollen.
关键词：allergic conjunctivitis;Japanese cedar pollen;IgG antibody;chlorpheniramine;ketotifen;amlexanox