文章基本信息

标题：Gastric Anti-ulcer Activity of Several α, β-Unsaturated Carbonyl Compounds in Rat
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作者：Alejandra O.M. MARIA ; Osvaldo DONADEL ; Graciela H. WENDEL 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2000
卷号：23
期号：5
页码：555-557
DOI：10.1248/bpb.23.555
出版社：The Pharmaceutical Society of Japan
摘要：The gastric cytoprotective activity of several molecules containing an α, β-unsaturated carbonyl system is reported. We attributed this gastroprotective activity to the presence of a non-hindered Michael acceptor in the molecules assayed and suggested that the mechanism of protection would involve, at least in part, a nucleophilic attack of the sulphydryl group of the gastric mucosa to the β carbon of the Michael acceptors of the compounds assayed.
关键词：gastric anti-ulcer activity;gastric protection;Michael acceptor;ethanol-induced injury