文章基本信息

标题：Effects of Highly Purified Ethyl All-cis-5, 8, 11, 14, 17-icosapentaenoate (EPA-E) on Rabbit Platelets
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作者：Masami SATO ; Yukio KATSUKI ; Kaoru FUKUHARA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1993
卷号：16
期号：4
页码：362-367
DOI：10.1248/bpb.16.362
出版社：The Pharmaceutical Society of Japan
摘要：The effects of ethyl all-cis-5, 8, 11, 14, 17-icosapentaenoate (EPA-E), highly purified ethyl ester of icosapentaenoic acid (EPA), on rabbit platelets were studied. In in vitro, highly purified EPA (62.5-3000 μM) suppressed the platelet aggregation induced by collagen, arachidonic acid (AA) and adenosine diphosphate (ADP). In ex vivo, a single administration of EPA-E (300 and 1000 mg/kg, p.o.) and repeated administrations (30 and 300 mg/kg/d, p.o.) for 2 weeks showed no effects on collagen-, AA- and ADP-induced platelet aggregation. Repeated administrations (30 and 300 mg/kg/d, p.o.) for 4 weeks suppressed the collagen-induced platelet aggregation, but not the AA- and ADP-induced platelet aggregation. Repeated administrations for 4 weeks also suppressed thromboxane B₂ (TXB₂) formation induced by collagen, but a single administration and repeated administrations for 2 weeks failed to inhibit TXB₂ formation. The EPA level in the platelet phospholipids increased slightly with a single administration, and increased markedly with repeated administrations for 2 and 4 weeks. The AA level in the phospholipids showed practically no changes with a single and repeated administrations. These results suggested that highly purified EPA-E could reduce platelet aggregability by the change of the EPA level in the platelet phospholipids and should allow for a reasonable period of administration.
关键词：ethyl all-cis-5, 8, 11, 14, 17-icosapentaenoate (EPA-E);platelet aggregation;thromboxane A2;fatty acid composition;rabbit