文章基本信息

标题：Effect of Spacer Groups Connecting Insulin with Fluorophore in Gly(A1)-sulfobenzoxadiazole-Labeled Insulins on the Immunoreactivity toward Anti-insulin Antibody
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作者：Masahiko NANAMI ; Kiyoshi ZAITSU ; Yosuke OHKURA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1993
卷号：16
期号：5
页码：516-517
DOI：10.1248/bpb.16.516
出版社：The Pharmaceutical Society of Japan
摘要：The immunoreactivity (specific binding) of three Gly(A1)-sulfobenzoxadiazole-labeled insulins which have different spacer groups, Gly(A1)-[3-(4-sulfobenzoxadiazol-7-ylthio)propanoyl]-insulin, Gly(A1)-[2-(4-sulfobenzoxadiazol-7-ylthio)acetyl]-insulin, Gly(A1)-[3-carboxy-2(or 3)-(4-sulfobenzoxadiazol-7-ylthio)propanoyl]-insulin, toward an antiporcine insulin monoclonal antibody was investigated, where solid-phase fluoroimmunoassay technique was utilized. The immunoreactivities of three labeled insulins were 2.1, 1.8 and 1 in that order.
关键词：sulfobenzoxadiazolyl insulin;spacer group;fluoroimmunoassay;porcine insulin;solid-phase antibody