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标题：Effects of Insulin and 1α-Hydroxy Vitamin D3 on Streptozotocin-Induced Diabetic Rats Fed a Low Zinc Diet
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作者：Takeshi MINAMI ; Hiroto SASAKI ; Yuko OKAZAKI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1993
卷号：16
期号：5
页码：468-470
DOI：10.1248/bpb.16.468
出版社：The Pharmaceutical Society of Japan
摘要：Streptozotocin-induced diabetic rats (LZ-DM rats) developed nephrocalcinosis after being fed a low zinc diet for 4 weeks. However, administration of 1α-hydroxy vitamin D₃ (1-OHD₃) or insulin inhibited the formation of nephrocalcinosis.The urinary calcium level increased when 1-OHD₃ was administered to these rats, but decreased in the group receiving insulin. It was also observed that the femur recovered its hardness when insulin was administered, although the hardness in the LZ-DM rats remained lower than that of the control rats. Rat femur hardness, however, did not completely recover with 1-OHD₃ treatment.These results indicate that the effects of insulin and 1-OHD₃ differ, even though nephrocalcinosis was reduced by administration of either insulin or 1-OHD₃. It appears that insulin assists bone formation, and the 1-OHD₃ hastens calcium excretion.
关键词：nephrocalcinosis;insulin;1α-hydroxy vitamin D3;diabetes;low zinc diet;femur