文章基本信息

标题：Pharmacological Modulation of Antigen-Induced Airway Hyperresponsiveness by Thromboxane A2 Inhibitors in Guinea Pigs
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作者：Hiroichi NAGAI ; Fumio TSUJI ; Shouichi GOTO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1993
卷号：16
期号：11
页码：1099-1103
DOI：10.1248/bpb.16.1099
出版社：The Pharmaceutical Society of Japan
摘要：The effects of OKY-046 (thromboxane A₂ (TXA₂) synthetase inhibitor) and ONO-3708 (TXA₂ receptor antagonist) on antigen-induced airway hyperreactivity in guinea pigs were investigated. Ketotifen was used as a reference drug. Seven inhalations of an antigen into actively sensitized animals resulted in an increase in airway reactivity to acetylcholine. Twenty-four hours after the final inhalation, the number of leukocytes (macrophages, neutrophils, eosinophils and lymphocytes) and the quantity of mediators (thromboxane B₂, leukotriene D₄ and histamine) in bronchoalveolar lavage fluid increased.All examined drugs inhibited the antigen-induced airway hyperreactivity to acetylcholine. Whereas ketotifen inhibited an accumulation of inflammatory cells (eosinophils and neutrophils) in bronchoalveolar lavage fluid, OKY-046 and ONO-3708 had no effect on the accumulation of inflammatory cells. OKY-046, but not ketotifen and ONO-3708, inhibited an increase of thromboxane B₂ in the bronchoalveolar lavage fluid after antigen provocation.These results suggest the participation of TXA₂ in the onset of antigen-induced airway hyperresponsiveness in guinea pigs, and the efficacy of TXA₂ inhibitors, without affecting the accumulation of inflammatory cells in bronchoalveolar lavage fluid.
关键词：airway hyperreactivity;thromboxane A2;airway inflammation;OKY-046;ONO-3708