文章基本信息

标题：Inhibitory Effect of Clindamycin on Production of β-Lactamase in β-Lactam-Resistant Bacteria
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作者：Toshiaki NISHIHATA ; Sachiyo KUNIEDA ; Chikara NAKAHAMA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：5
页码：715-720
DOI：10.1248/bpb.17.715
出版社：The Pharmaceutical Society of Japan
摘要：The inhibitory effect of clindamycin on β-lactamase biosynthesis was investigated in β-lactam resistant bacteria with inducible and/or constitutive production of the enzyme (s). Clinical isolates of Enterobacter cloacae (E. cloacae) and Pseudomonas aeruginosa (P. aeruginosa) were examined. Three strains of each, against which sulbactam at 8μg/ml reduced the minimum inhibitory concentration (MIC) of cefoperazone (CPZ) at least 4 fold, were studied in greater detail. Although clindamycin had no appreciable effect on bacteria growth at concentrations up to 50μg/ml, it suppressed inducible β-lactamase biosynthesis almost completely at a concentration of 20μg/ml. There was also a significant reduction of constitutive enzyme biosynthesis by clindamycin at 50 μg/ml. Thus, it was estimated that a high concentration of clindamycin was required to suppress β-lactamase biosynthesis in β-lactamase producing bacteria of the constitutive type.
关键词：β-lactamase;clindamycin;β-lactam antibiotics;E. cloacae;P. aeruginosa