文章基本信息

标题：Cu-ATSM, an Intracellular-Accessible Superoxide Dismutase (SOD)-Like Copper Complex : Evaluation in an Ischemia-Reperfusion Injury Model
本地全文：下载
作者：Kouichi WADA ; Yasuhisa FUJIBAYASHI ; Naoyuki TAJIMA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：5
页码：701-704
DOI：10.1248/bpb.17.701
出版社：The Pharmaceutical Society of Japan
摘要：We have reported a stable superoxide dismutase (SOD)-like copper complex, Cu-ATSM, which shows high membrane permeability and distribution to the brain or heart. In this study, we evaluated the protective effects of Cu-ATSM on superoxide-mediated tissue damage caused by ischemia-reperfusion using an isolated perfused rat heart model. Lipid peroxidation levels in the Cu-ATSM treated group were lower than those in the non-treated group. Furthermore, released creatine phosphokinase into the perfusate, a marker of tissue damage, was reduced by Cu-ATSM treatment. These results indicated the possibility of Cu-ATSM being an effective SOD-like drug for the treatment of superoxide-mediated damage, such as ischemia-reperfusion injury.
关键词：ischemia-reperfusion;copper complex;superoxide dismutase