文章基本信息

标题：Suppression of Hyperalgesia in Streptozotocin-Induced Diabetic Mice by a Lipopolysaccharide from Pantoea agglomerans
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作者：Junzo KAMEI ; Yuriko IWAMOTO ; Tsutomu SUZUKI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：5
页码：632-634
DOI：10.1248/bpb.17.632
出版社：The Pharmaceutical Society of Japan
摘要：The ability of a lipopolysaccharide from Pantoea agglomerans (LPSp) to relieve hyperalgesia was examined by observing its inhibition of the decrease in the threshold for nociceptive perception, as determined by the tail-pinch test, in streptozotocin-induced diabetic mice. Subcutaneous injection of LPSp suppressed hyperalgesia in streptozotocin-induced diabetic mice and also exerted a therapeutic effect on hyperalgesia in these animals. The present data suggest that LPSp may be effective in relieving the pain associated with diabetic neuropathy.
关键词：diabetes;hyperalgesia;painful diabetic neuropathy;lipopolysaccharide;macrophage