文章基本信息

标题：Studies on Pharmacological Activation of Human Immunoglobulin G by Chemical Modification and Active Subfragments. XIII. Effect of Carboxamidemethylated Fc Fragment (CM-Fc) on Type II Collagen-Induced Arthritis in DBA/1J Mice
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作者：Tsutomu MIMURA ; Masaaki ITOH ; Hiroko GOHGI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：5
页码：623-626
DOI：10.1248/bpb.17.623
出版社：The Pharmaceutical Society of Japan
摘要：The effect of carboxamidemethylated Fc fragment (CM-Fc) from human immunoglobulin G (IgG) on type II collagen (C II)-induced arthritis (CIA) in DBA/1J mice was studied. CM-Fc suppressed the development of CIA while Fc fragment did not. CM-Fc inhibited the increase in serum anti-C II IgG. CM-Fc suppressed C II-induced delayed type hypersensitivity (DTH) in DBA/1J mice. Moreover, the C II-induced proliferation of splenocytes from mice immunized with C II was suppressed by the administration of CM-Fc. Following an analysis of the lymphocyte population, a decreased percentage of B220⁺ cells and ratio of L3T4⁺/Ly-2⁺ cells was observed in lymph nodes of CM-Fc administered mice as compared with those of control group. These results suggest that CM-Fc inhibits CIA by regulating lymphocyte function.
关键词：carboxamidemethylated Fc (CM-Fc);type II collagen;arthritis;DBA/1J mouse;delayed type hypersensitivity