文章基本信息

标题：Inhibition of Helicobacter pylori Urease Activity by Hydroxamic Acid Derivatives
本地全文：下载
作者：Shinjiro ODAKE ; Tadanori MORIKAWA ; Mamiko TSUCHIYA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：10
页码：1329-1332
DOI：10.1248/bpb.17.1329
出版社：The Pharmaceutical Society of Japan
摘要：Helicobacter pylori (HP) produces strong urease [EC 3.5.1.5], which is considered to play a role in the pathogenesis of gastritis and peptic ulcers. Inhibitions against this enzyme have been studied with hydroxamic acid (HXA) derivatives of aliphatic or aromatic carboxylic acids, amino acids and dipeptides. A number of HXAs potently inhibited the urease (I₅₀ values were near the order of 10^-6M), and H-Ile-Gly-NHOH (I₅₀=0.20×10^-6M) was the most potent inhibitor among the derivatives. HP urease was inhibited more potently, in general, than Jack bean (JB) urease by HXAs, and a correlation between the chemical structures of HXA derivatives and their inhibitory effects on HP urease was observed, in comparison with JB urease.
关键词：Helicobacter pylori urease;inhibition;hydroxamic acid;Jack bean urease