文章基本信息

标题：ENHANCEMENT OF THE INTESTINAL ABSORPTION OF A CYCLOSPORINE DERIVATIVE BY MILK FAT GLOBULE MEMBRANE
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作者：Hitoshi SATO ; HongXing LIU ; Isao ADACHI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：11
出版社：The Pharmaceutical Society of Japan
摘要：A cyclosporine derivative, dihydrocyclosporine D, was used for the evaluation of milk fat globule membrane (MFGM) as an emulsifier of lipophilic cyclopeptides. As compared with olive oil formulation, MFGM emulsion significantly enhanced the blood and lymphatic fluid concentrations of the cyclosporine derivative after intraduodenal dosing in rats. Thus, it was suggested that MFGM can be used as an intestinal absorption enhancer of cyclosporines.