文章基本信息

标题：Effects of a Nitric Oxide Synthase Inhibitor on Hypophagia Induced by the Peripheral 5-HT Receptor Agonists, α-Methyl-5-hydroxytryptamine and 5-Carboxamidotryptamine in Rats
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作者：Yumi SUGIMOTO ; Toshiko NOMA ; Tomoko YOSHIKAWA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2000
卷号：23
期号：12
页码：1514-1516
DOI：10.1248/bpb.23.1514
出版社：The Pharmaceutical Society of Japan
摘要：We investigated the effects of the nitric oxide (NO) synthase inhibitor, N^G -nitro-L-arginine methyl ester (L-NAME) on hypophagia in rats elicited by α-methyl-5-hydroxytryptamine (α-methyl-5-HT) and 5-carboxamidotryptamine (5-CT) which are suggested to be mediated by the peripheral 5-HT_2A and 5-HT₇ receptor, respectively. Both α-methyl-5-HT and 5-CT apparently inhibited food intake in food-deprived rats. L-NAME significantly enhanced α-methyl-5-HT-elicited hypophagia, while it inhibited 5-CT-elicited hypophagia. These results suggest that NO is differentialy related to α-methyl-5-HT and 5-CT-induced hypophagia and that NO may play a role in hypo- and hyperphagia.
关键词：5-HT;NO;food intake;5-HT2A receptor;5-HT7 receptor;α-methyl-5-HT;5-CT