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标题：Anti-estrogenic Activity of Diesel Exhaust Particles
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作者：Shinji TANEDA ; Hideyuki HAYASHI ; Masakatsu SAKATA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2000
卷号：23
期号：12
页码：1477-1480
DOI：10.1248/bpb.23.1477
出版社：The Pharmaceutical Society of Japan
摘要：Estrogenic and anti-estrogenic activities of diesel exhaust particles (DEP) were evaluated using yeast cells expressing the human estrogen receptor and the responsive element regulating the expression of the receptor gene for β-galactosidase (Routledge and Sumpter, 1996). It was found that a suspension of whole DEP suspension is not estrogenic but that this preparation possesses the ability to reduce the estrogen-dependent reporter activity. DEP were serially extracted with hexane, benzene, dichloromethane, methanol, and 1 M ammonia, and the estrogenic and anti-estrogenic activities of these preparations were determined. None of the extracts of DEP were estrogenic, but the extracts of benzene, dichloromethane and methanol possessed anti-estrogenic activity, and the activity of estrogen in the presence of hexane extract was slightly decreased. These results indicated that DEP contain heterologous compounds having anti-estrogenic activity. It is thought that those compounds in DEP can modulate the activity of estrogen, leading to the distribution of balance between estrogen and androgen. In this paper, the environmental effects of DEP in relation to the endocrine disrupting effect or organic compounds in DEP are discussed.
关键词：diesel exhaust particle;anti-estrogenic activity;endocrine disrupter