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标题：Effect of Ethanol Amine Plasmalogens on Fe-Induced Peroxidation of Arachidonic Acid in Dipalmitoylphosphatidylcholine Vesicles
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作者：Maria Fausta OMODEO SALE ; Angela Maria RIZZO ; Massimo MASSERINI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2000
卷号：23
期号：12
页码：1410-1413
DOI：10.1248/bpb.23.1410
出版社：The Pharmaceutical Society of Japan
摘要：We have investigated the influence of ethanolamine plasmalogens on iron-induced oxidation of arachidonic acid in dipalmitoylphosphatidylcholine (DPPC) vesicles. Lipoperoxidation was induced by the addition of 50 μM FeSO₄ and studied above (50 °C) and below (15°C) the gel-to liquid transition temperature of the vesicles, at two different pH values (7.4 or 6.4). The extent of peroxidation was measured as thiobarbituric reactive product formed and the influence exerted by ethanolamine plasmalogens (PEPL) in this process was compared to that of dipalmitoylphosphatidylethanolamine (DPPE) and discylphosphatidylethanolamines (DAPE). The extent of peroxidation of arachidonic acid embedded in DPPC vesicles was similar at the two temperatures and greater at 50°C under acidic conditions. However, the peroxidative process was significantly decreased at 50°C in the presence of PEPL, but not of DPPE or DAPE and the inhibitory effect was enhanced at pH 6.4. The possibility that a different phase distribution of the phospholipids, namely a transition from a lamellar to a hexagonal phase, may play a role in the scavenger effect of ethanolamine plasmalogens is discussed.
关键词：plasmalogens;lipid peroxidation;phospholipids