文章基本信息

标题：A Convenient Screening Test for Hypoxic Cell Radiosensitizers/Cytotoxins
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作者：Hitoshi HORI ; Hideakira YOKOYAMA ; Hideko NAGASAWA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：12
页码：1676-1678
DOI：10.1248/bpb.17.1676
出版社：The Pharmaceutical Society of Japan
摘要：A convenient in vitro screening test using E. coli B/r for evaluating a variety of hypoxic cell radiosensitizers/hypoxic cell cytotoxins has been developed for the initial selection of candidates in medicinal/organic chemistry laboratories. E. coli cells were used for convenience since : (1) the bacterium is grown using commercially available broths, where it multiplies repidly, and requires little specialized equipment for growth and handling. (2) More is known about the genetics and biochemistry of the radiation damage to these cells and their repair than any other organism.
关键词：hypoxic cell radiosensitizer;hypoxic cell cytotoxin;radiosensitization;E. coli B/r screening test;EMT6/KU cell in vitro assay