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标题：Inhibitory Effect of Alkaloids Extracted from the Stem Bark of Hunteria zeylanica on 5-Lipoxygenase Activity in Vitro
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作者：Wantana REANMONGKOL ; Michihisa TOHDA ; Kinzo MATSUMOTO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1995
卷号：18
期号：6
页码：910-912
DOI：10.1248/bpb.18.910
出版社：The Pharmaceutical Society of Japan
摘要：The effects of alkaloid extract from the stem bark of Hunteria zeylanica GARD. (H. zeylanica) on the activities of cyclooxygenase and 5-lipoxygenase in A23187-stimulated rat mast cells were investigated. H. zeylanica alkaloid extract (0.3-300μg/ml) inhibited leukotriene C₄ (LTC₄) production by 5-lipoxygenase in a concentration-dependent manner and it blocked the production by 50% at 300 μg/ml. On the other hand, the extract had no effect on prostaglandin D₂ (PGD₂) production by cyclooxygenase. Neither (-)-eburnamine nor pleiomutinine, major constituents of H. zeylanica alkaloid extract, inhibited the production of PGD₂ and LTC₄ in the A23187-stimulated mast cells. The inhibition of arachidonic acid metabolism via 5-lipoxygenase pathway may be due to minute amounts of other components as stated in the Discussion.
关键词：Hunteria zeylanica;alkaloid extract;5-lipoxygenase;inhibition;rat mast cell