文章基本信息

标题：Structure-Activity Correlationship and Strain Specificity of Polyoxometalates in Anti-human Immunodeficiency Virus Activity
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作者：Yoshio INOUYE ; Yasuhiro FUJIMOTO ; Masanori SUGIYAMA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1995
卷号：18
期号：7
页码：996-1000
DOI：10.1248/bpb.18.996
出版社：The Pharmaceutical Society of Japan
摘要：The anti-human immunodeficiency virus (HIV) activity of polyoxometalates of representative structural families, such as Keggin, lacunary Keggin, trivacant Keggin, Keggin sandwich, Wells-Dawson and Wells-Dawson sandwich, was determined using two strains of HIV type 1 (HIV-1_HTLV-IIIBand HIV-1_SF-2H). The compounds were preferably selected to cover both polyoxotungstates and polyoxomolybdates in each structural family. In general, polyoxotungstates of Keggin, lacumary Keggin, trivacant Keggin, Keggin sandwich, Wells-Dawson and Wells-Dawson sandwich structures showed anti-HIV-1_HTLV-IIIBactivity, whereas most compounds not included in these structural categories were inactive. Among the compounds with a potent anti-HIV-1_HTLV-IIIBactivity, those of Keggin and its closely related structural families (lacunary Keggin, trivacant Keggin and Keggin sandwich) inhibited the cytopathogenicity and syncytium formation caused by HIV-1_SF-2Hto a much higher extent compared with HIV-1_HTLV-IIIB-related ones. The difference between the spectra of anti-HIV-1_HTLV-IIIBactivity and the specificity for HIV-1_SF-2Hmight result from differential structural requirements in these functions.
关键词：polyoxometalate;human immunodeficiency virus;strain specificity;syncytium formation;cytopathogenicity