文章基本信息

标题：Application of Curdlan to Controlled Drug Delivery. III. Drug Release from Sustained Release Suppositories in Vitro
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作者：Motoko KANKE ; Emi TANABE ; Hirokazu KATAYAMA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1995
卷号：18
期号：8
页码：1154-1158
DOI：10.1248/bpb.18.1154
出版社：The Pharmaceutical Society of Japan
摘要：The use of curdlan, a natural β-1, 3-glucan, in the preparation of sustained release suppositories was studied in vitro. To prepare the suppositories, indomethacin, prednisolone or salbutamol sulfate was mixed with curdlan gel. Preparation conditions, including heating time and curdlan concentrations of 5 and 10%, had little effect on the drug release. The tonicity (hypotonic or isotonic) of the media for the suppository preparation and for in vitro drug release study also had little effect on drug release. However, the heating temperature during gel preparation, the drug amount in the suppository and the type of release media did affect drug release. It was found that drug release was sustained and diffusion-controlled in the three drugs. And finally, curdlan can be applicable for use in a sustained release suppository.
关键词：curdlan;sustained release;suppository;gel;diffusion-controlled