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标题：Potentiating Effects on Pilocarpine-Induced Saliva Secretion, by Extracts and N-Containing Sugars Derived from Mulberry Leaves, in Streptozocin-Diabetic Mice
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作者：Fu-jun CHEN ; Noboru NAKASHIMA ; Ikuko KIMURA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1995
卷号：18
期号：12
页码：1676-1680
DOI：10.1248/bpb.18.1676
出版社：The Pharmaceutical Society of Japan
摘要：The effects of hot water extracts and six compounds of N-containing sugars, 1-deoxynojirimycin (DNJ), N-methyl-DNJ (N-Me-DNJ), 2-O-α-D-galactopyranosyl-DNJ (GAL-DNJ), fagomine, 1, 4-dideoxy-1, 4-imino-D-arabinitol (DAB), and 1, 2α, 3β, 4α-tetrahydroxynortropane (calystegin B₂), derived from mulberry leaves (Morus alba L.), were investigated on pilocarpine-induced saliva secretion in streptozocin (STZ)-induced diabetic mice. The extracts (100 and 200 mg/kg, i.p.) significantly potentiated the pilocarpine-induced salivary flow but not the protein content. The component compounds (37.5-300 μmol/kg) potentiated the saliva secretion, and the potency order was DAB>fagomine>GAL-DNJ. Only fagomine significantly increased the protein content in the saliva. The potentiation of pilocarpine-induced salivary flow was correlated with anti-hyperglycemic effects by the extract and GAL-DNJ from mulberry leaves in the same dose ranges.
关键词：anti-hyperglycemic saliva secretion;pilocarpine;STZ-diabetic mouse;mulberry leave;GAL-DNJ;fagomine